IFNγ signals control germinal centre formation
نویسندگان
چکیده
منابع مشابه
Regulatory T cells and control of the germinal centre response
Germinal centres (GCs) are specialised lymphoid microenvironments that form in secondary B-cell follicles upon exposure to T-dependent antigens. In the GC, clonal expansion, selection and differentiation of GC B cells result in the production of high-affinity plasma cells and memory B cells that provide protection against subsequent infection. The GC is carefully regulated to fulfil its critica...
متن کاملIntroduction to the Proceedings of the 12Th Germinal Centre Conference — Thirty Years of Germinal Centre Conferences
"In Vivo Veritas": Under this motto, the twelfth socalled Germinal Centre Conference was held in Graz, Austria, July 1 to 5, 1996, with Prof. Konrad Schauenstein chairing the organizing committee, with the assistance of Dr. Richard Boyd (Australia). Despite the progress that is being made using in vitro models, some immunologists believe that "the proof of the pudding is in the eating", that is...
متن کاملSignals sustaining human immunoglobulin V gene hypermutation in isolated germinal centre B cells.
Affinity maturation of antibody responses depends on somatic hypermutation of the immunoglobulin V genes. Hypermutation is initiated specifically in proliferating B cells in lymphoid germinal centres but the signals driving this process remain unknown. This study identifies signals that promote V gene mutation in human germinal centre (GC) B cells in vitro. Single GC B cells were cultured by li...
متن کاملLow prevalence of ectopic germinal centre formation in patients with HTLV-I-associated Sjogren's syndrome.
Title Low prevalence of ectopic germinal centre formation in patients with HTLV-I-associated Sjogren's syndrome. Author(s) Nakamura, Hideki; Kawakami, Atsushi; Hayashi, Tomayoshi; Nakamura, Tatsufumi; Iwamoto, Naoki; Yamasaki, Satoshi; Ida, Hiroaki; Eguchi, Katsumi Citation Rheumatology, 48(7), pp.854-855; 2009 Issue Date 2009-07 URL http://hdl.handle.net/10069/23205 Right (c) The Author 2009. ...
متن کاملRobot control system using SMR signals detection
One of the important issues in designing a brain-computer interface system is to select the type of mental activity to be imagined. In some of these systems, mental activity varies with user intent and action that must be controlled by the brain-computer system, and in a number of other signals, the received signals contain the same activity-related mental activity that should be performed by t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2016
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2016.71